LncRNA GAS8-AS1 is downregulated, correlates with early-stage disease and lymph node metastasis, and its knockdown promotes proliferation, migration, and invasion in differentiated thyroid cancer - Takeaways - MDSpire

LncRNA GAS8-AS1 is downregulated, correlates with early-stage disease and lymph node metastasis, and its knockdown promotes proliferation, migration, and invasion in differentiated thyroid cancer

  • By

  • Avaniyapuram Kannan Murugan

  • Hindi Al-Hindi

  • Ali S. Alzahrani

  • June 8, 2026

  • 0 min

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  • 1

    GAS8-AS1 expression is significantly downregulated in differentiated thyroid cancers compared to normal tissues.

  • 2

    Lower GAS8-AS1 expression correlates with early-stage disease and lymph node metastasis in differentiated thyroid cancer.

  • 3

    Silencing GAS8-AS1 enhances proliferation, migration, and invasion in thyroid cancer cell lines.

  • 4

    GAS8-AS1 may act as a tumor suppressor, with its downregulation linked to disease progression in differentiated thyroid cancer.

  • 5

    The consistent loss of GAS8-AS1 expression suggests its potential as a diagnostic and prognostic biomarker in differentiated thyroid cancers.

Original Source(s)

LncRNA GAS8-AS1 is downregulated, correlates with early-stage disease and lymph node metastasis, and its knockdown promotes proliferation, migration, and invasion in differentiated thyroid cancer

  • by Avaniyapuram Kannan Murugan, Hindi Al-Hindi, Ali S. Alzahrani

  • June 8, 2026

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