Neutrophil-to-lymphocyte ratio as a practical alternative to mHLA-DR measurement in delayed sepsis-induced immunosuppression - Takeaways - MDSpire

Neutrophil-to-lymphocyte ratio as a practical alternative to mHLA-DR measurement in delayed sepsis-induced immunosuppression

  • By

  • Thomas Lafon

  • Fabienne Venet

  • Anne-Claire Lukaszewicz

  • Guillaume Monneret

  • March 31, 2026

  • 0 min

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  • 1

    Neutrophil-to-lymphocyte ratio (NLR) can serve as a practical surrogate for mHLA-DR in assessing immunosuppression in septic patients.

  • 2

    NLR > 10 correlates with low mHLA-DR values and identifies patients with immunosuppressive features, including lymphopenia.

  • 3

    The study found 64% concordance between NLR and mHLA-DR, indicating NLR's potential as an accessible marker for immunosuppression.

  • 4

    Elevated NLR reflects multiple immuno-inflammatory features, making it a useful provisional marker for identifying patients needing immunotherapy.

  • 5

    Further validation of NLR is necessary to establish clinically relevant thresholds for septic and other ICU patient populations.

Original Source(s)

Neutrophil-to-lymphocyte ratio as a practical alternative to mHLA-DR measurement in delayed sepsis-induced immunosuppression

  • by Thomas Lafon, Fabienne Venet, Anne-Claire Lukaszewicz, Guillaume Monneret

  • March 31, 2026

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