TREM1 unleashes immunosuppression in glioma: targeting macrophage polarization as a new therapeutic vulnerability - Takeaways - MDSpire

TREM1 unleashes immunosuppression in glioma: targeting macrophage polarization as a new therapeutic vulnerability

  • By

  • Chao Zhang

  • Da Teng

  • Chao Wang

  • Runsheng Feng

  • Xinqi Huang

  • Ben Hu

  • Yu Wang

  • Ning Lin

  • Cheng Zhang

  • July 3, 2026

  • 0 min

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  • 1

    TREM1 expression is upregulated in glioma and correlates with higher malignant potential, indicating its role as a prognostic biomarker.

  • 2

    TREM1 is associated with M2-type macrophages and promotes their polarization, contributing to immune suppression in glioma.

  • 3

    Knockdown of TREM1 in macrophages reduces glioma cell proliferation, invasion, and migration capabilities.

  • 4

    The study utilized bioinformatics, single-cell sequencing, and co-culture models to explore TREM1's role in glioma.

  • 5

    Targeting TREM1 may provide a novel strategy to enhance immunotherapy efficacy for glioma treatment.

Original Source(s)

TREM1 unleashes immunosuppression in glioma: targeting macrophage polarization as a new therapeutic vulnerability

  • by Chao Zhang, Da Teng, Chao Wang, Runsheng Feng, Xinqi Huang, Ben Hu, Yu Wang, Ning Lin, Cheng Zhang

  • July 3, 2026

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