Prenatal Exposure to Acid-Suppressive Medications and Incident Risk of Inflammatory Bowel Disease in Children - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Impact of Prenatal Use of Acid-Suppressive Drugs on the Development of Inflammatory Bowel Disease in Offspring

  • By

  • Jiyeon Oh

  • Jaeyu Park

  • Hyunjee Kim

  • Hyesu Jo

  • Kyeongmin Lee

  • Yeona Jo

  • Seohyun Hong

  • Sooji Lee

  • Selin Woo

  • Yerin Hwang

  • Jinseok Lee

  • Tae Hyeong Kim

  • Hayeon Lee

  • June 24, 2026

Share

  • 1

    Prenatal use of acid-suppressive medications, including PPIs and H2RAs, is common among pregnant women experiencing gastroesophageal reflux.

  • 2

    Emerging evidence suggests that prenatal exposure to acid-suppressive drugs may increase the risk of allergic diseases and congenital malformations in children.

  • 3

    The study examines the association between prenatal acid-suppressive medication exposure and the risk of pediatric-onset inflammatory bowel disease (IBD).

  • 4

    A nationwide birth cohort in South Korea, covering nearly 3 million mother-child pairs, was utilized to assess this association.

  • 5

    Prenatal exposure to acid-suppressive medications was defined as having one or more prescriptions during pregnancy, with IBD diagnosed postnatally.

Original Source(s)

Prenatal Exposure to Acid-Suppressive Medications and Incident Risk of Inflammatory Bowel Disease in Children

  • by Jiyeon Oh, Jaeyu Park, Hyunjee Kim, Hyesu Jo, Kyeongmin Lee, Yeona Jo, Seohyun Hong, Sooji Lee, Selin Woo, Yerin Hwang, Jinseok Lee, Tae Hyeong Kim, Hayeon Lee

  • June 24, 2026

Related Content

Intestinal subepithelial myofibroblasts in inflammatory bowel disease: fibroblast heterogeneity, fibrosis, and therapeutic targeting

Five-Year Outcomes and Disease Trajectories in Moderate-to-Severe Ulcerative Colitis: A Korean Multicenter Inception Cohort

TNFAIP3/A20 dysfunction drives innate and sterile hyperinflammation