Does HPV Vaccination Lower Cancer Risk in Males?

A large real-world study found a lower incidence of any HPV-related cancer among vaccinated males

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The 9-valent HPV vaccine significantly reduces the incidence of HPV-related cancers in males aged 9 to 26 years.
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A study analyzed over 615,000 vaccinated and 2.3 million unvaccinated males, showing a 46% lower cancer risk among vaccinated individuals.
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The primary driver of the reduced cancer risk was head and neck cancer, while other cancer types could not be evaluated separately due to low event counts.
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Limitations of the study include potential misclassification of cancer diagnoses and unaccounted vaccination records outside the study centers.
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The findings support the expansion of sex-neutral HPV vaccination programs, emphasizing the need for vaccination in young males.

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