Does HPV Vaccination Lower Cancer Risk in Males? - Takeaways - MDSpire

Does HPV Vaccination Lower Cancer Risk in Males?

A large real-world study found a lower incidence of any HPV-related cancer among vaccinated males

  • By

  • Kerri Miller

  • April 17, 2026

  • 3 min

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  • 1

    The 9-valent HPV vaccine significantly reduces the incidence of HPV-related cancers in males aged 9 to 26 years.

  • 2

    A study analyzed over 615,000 vaccinated and 2.3 million unvaccinated males, showing a 46% lower cancer risk among vaccinated individuals.

  • 3

    The primary driver of the reduced cancer risk was head and neck cancer, while other cancer types could not be evaluated separately due to low event counts.

  • 4

    Limitations of the study include potential misclassification of cancer diagnoses and unaccounted vaccination records outside the study centers.

  • 5

    The findings support the expansion of sex-neutral HPV vaccination programs, emphasizing the need for vaccination in young males.

Original Source(s)

Does HPV Vaccination Lower Cancer Risk in Males?

  • by Kerri Miller

  • April 17, 2026

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