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Seminal fibrils may facilitate mpox infection

Seminal fluid increased mpox virus infection across primary cells and viral isolates, with semen-derived amyloid fibrils promoting viral attachment and uptake.

  • By

  • Andrea Surnit

  • September 9, 2026

  • 4 min

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  • 1

    Human seminal fluid enhances mpox virus infection in primary human cells, increasing viral attachment and uptake.

  • 2

    Seminal fluid from all tested donors increased mpox-positive cells in fibroblasts and keratinocytes.

  • 3

    Both SEVI and SEM, semen-derived amyloid fibrils, increased mpox infection in a dose-dependent manner.

  • 4

    SEVI enhanced infection across multiple mpox clades and other viruses like cowpox and camelpox.

  • 5

    The study indicates that semen-derived fibrils may increase the efficiency of viral transmission and enhance infection.

Original Source(s)

Seminal fibrils may facilitate mpox infection

  • by Andrea Surnit

  • September 9, 2026

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