Seminal fibrils may facilitate mpox infection
Seminal fluid increased mpox virus infection across primary cells and viral isolates, with semen-derived amyloid fibrils promoting viral attachment and uptake.
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By
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Andrea Surnit
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September 9, 2026
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1
Human seminal fluid enhances mpox virus infection in primary human cells, increasing viral attachment and uptake.
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2
Seminal fluid from all tested donors increased mpox-positive cells in fibroblasts and keratinocytes.
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3
Both SEVI and SEM, semen-derived amyloid fibrils, increased mpox infection in a dose-dependent manner.
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4
SEVI enhanced infection across multiple mpox clades and other viruses like cowpox and camelpox.
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The study indicates that semen-derived fibrils may increase the efficiency of viral transmission and enhance infection.
