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1
T lymphocytes play a crucial role in the adaptive immune system, orchestrating pathogen-specific responses and long-term immunological memory.
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2
Long-lasting T cell subsets include naive T cells, stem cell-like memory T cells, central memory T cells, effector memory T cells, and tissue-resident memory T cells.
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3
Aging significantly impacts T cell maintenance, tissue tropism, and metabolic adaptation, influencing immune responses and cancer progression.
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4
Thymic involution leads to reduced naive T cell output, particularly affecting naive CD8+ T cells, while naive CD4+ T cells remain relatively stable.
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5
Changes in the naive T cell pool with age include an increase in CXCR3high cells and a shift towards a pro-inflammatory functional profile.
