Subtype-specific sonographic signatures and clinicopathological features of metaplastic breast cancer: a 50-case cohort study - Takeaways - MDSpire

Subtype-specific sonographic signatures and clinicopathological features of metaplastic breast cancer: a 50-case cohort study

  • By

  • Boxiong Wei

  • Zijing Fu

  • Yuhong Shao

  • Xiuming Sun

  • Luzeng Chen

  • July 2, 2026

  • 0 min

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  • 1

    Metaplastic breast cancer (MBC) is a rare and aggressive malignancy, accounting for less than 1% of all breast carcinomas.

  • 2

    The study analyzed 50 women with histologically confirmed MBC, focusing on subtype-specific sonographic features and clinicopathological characteristics.

  • 3

    The spindle cell subtype often presents with a pseudo-benign sonographic appearance, leading to potential diagnostic underestimation.

  • 4

    Squamous cell and mixed-type tumors more frequently exhibit heterogeneous echogenicity and complex cystic-solid components.

  • 5

    MBC shows a unique size-node dissociation pattern, with significant axillary lymph node metastasis rates despite large tumor sizes.

Original Source(s)

Subtype-specific sonographic signatures and clinicopathological features of metaplastic breast cancer: a 50-case cohort study

  • by Boxiong Wei, Zijing Fu, Yuhong Shao, Xiuming Sun, Luzeng Chen

  • July 2, 2026

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