Heart Failure Trajectories After Guideline-Directed Medical Therapy - Takeaways - MDSpire

Heart Failure Trajectories After Guideline-Directed Medical Therapy

  • By

  • Duy Do

  • Karthik Murugiah

  • Mitsuaki Sawano

  • Brianna M. Goodwin Cartwright

  • Samuel Gratzl

  • Lesley H. Curtis

  • Nicholas L. Stucky

  • May 21, 2026

  • 0 min

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  • 1

    Heart failure with reduced ejection fraction (HFrEF) has high morbidity and mortality, necessitating timely reassessment and treatment.

  • 2

    In a cohort of 340,305 individuals, only 33.8% underwent repeat echocardiograms within 12 months after initial HFrEF diagnosis.

  • 3

    Among patients reassessed, 62.7% transitioned to heart failure in remission (HFrEFrem), while 29.2% remained with persistent HFrEF.

  • 4

    Guideline-directed medical therapy (GDMT) use was modest, with only 45.2% of patients on recommended medications at 12 months.

  • 5

    The study highlights a gap between evidence and practice, emphasizing the need for standardized LVEF reassessment and sustained GDMT.

Original Source(s)

Heart Failure Trajectories After Guideline-Directed Medical Therapy

  • by Duy Do, Karthik Murugiah, Mitsuaki Sawano, Brianna M. Goodwin Cartwright, Samuel Gratzl, Lesley H. Curtis, Nicholas L. Stucky

  • May 21, 2026

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