Distribution of quorum-sensing genes (lasI, lasR, RhlI, and rhlR) among clinical isolates of biofilm-forming Pseudomonas aeruginosa in Northern Iran - Takeaways - MDSpire

Distribution of quorum-sensing genes (lasI, lasR, RhlI, and rhlR) among clinical isolates of biofilm-forming Pseudomonas aeruginosa in Northern Iran

  • By

  • Robabeh Gholami Aghamahali

  • Mahya Pahlavanian

  • Hamid Reza Goli

  • December 23, 2025

  • 0 min

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  • 1

    Pseudomonas aeruginosa is a significant opportunistic pathogen, causing severe infections and exhibiting high antibiotic resistance.

  • 2

    The bacterium's ability to form biofilms is crucial for chronic infections and contributes to multidrug-resistant strains.

  • 3

    Quorum sensing (QS) systems, including Las and Rhl, regulate biofilm formation and virulence in P. aeruginosa.

  • 4

    This study aimed to assess the prevalence of quorum-sensing genes lasI, lasR, rhlI, and rhlR in clinical isolates from Northern Iran.

  • 5

    Understanding the distribution of QS genes may aid in developing strategies for vaccine design against P. aeruginosa infections.

Original Source(s)

Distribution of quorum-sensing genes (lasI, lasR, RhlI, and rhlR) among clinical isolates of biofilm-forming Pseudomonas aeruginosa in Northern Iran

  • by Robabeh Gholami Aghamahali, Mahya Pahlavanian, Hamid Reza Goli

  • December 23, 2025

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