Pre-transplant microRNA serum profiles and association with acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation

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Serum microRNA profiles prior to transplantation can predict the risk and severity of acute graft-versus-host disease in allo-HSCT recipients.
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In a study of 78 allo-HSCT recipients, 23% developed aGVHD grade II–IV, highlighting the need for early predictive tools.
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Eight pretransplant miRNAs were identified as predictive markers for aGVHD, achieving an AUC of 0.855 in ROC analysis.
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Hierarchical clustering of miRNA profiles distinguished patients into high and low aGVHD risk groups, with significant differences in incidence.
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The findings support integrating pre-transplant miRNA profiling into assessments to guide personalized GVHD prophylaxis and monitoring.

Frontiers In Immunology

by Guido Smits, Silje Johansen, Kristin Paulsen Rye, Kimberley Joanne Hatfield, Franziska Görtler, Guro Kristin Melve, Håkon Reikvam
May 28, 2026

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