Integrin αVβ6: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease - Takeaways - MDSpire

Integrin αVβ6: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease

  • By

  • Dominik Roth

  • Miriam M Düll

  • Ludwig J Horst

  • Aylin Lindemann

  • Xenia Malzer

  • Kristina Koop

  • Sebastian Zundler

  • Marcel Vetter

  • André Jefremow

  • Raja Atreya

  • Carol Geppert

  • Sören Weidemann

  • Maximilian J Waldner

  • Peter Dietrich

  • Claudia Günther

  • Luis E Munoz

  • Martin Herrmann

  • Alexander Scheffold

  • Markus F Neurath

  • Jürgen Siebler

  • Christoph Schramm

  • Andreas E Kremer

  • Moritz Leppkes

  • August 30, 2024

  • 0 min

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  • 1

    Autoantibodies against integrin αVβ6 are strongly associated with ulcerative colitis and present in various liver diseases.

  • 2

    Anti-αVβ6 was found in 91% of ulcerative colitis patients and 73% of those with PSC-IBD.

  • 3

    Integrin αVβ6 is selectively expressed in disease-associated epithelia of both bile ducts and colon.

  • 4

    Anti-αVβ6 levels correlate moderately with intestinal disease activity in PSC-IBD but weakly with biliary disease.

  • 5

    The study aims to explore the presence and clinical relevance of anti-αVβ6 in PSC and its association with IBD.

Original Source(s)

Integrin αVβ6: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease

  • by Dominik Roth, Miriam M Düll, Ludwig J Horst, Aylin Lindemann, Xenia Malzer, Kristina Koop, Sebastian Zundler, Marcel Vetter, André Jefremow, Raja Atreya, Carol Geppert, Sören Weidemann, Maximilian J Waldner, Peter Dietrich, Claudia Günther, Luis E Munoz, Martin Herrmann, Alexander Scheffold, Markus F Neurath, Jürgen Siebler, Christoph Schramm, Andreas E Kremer, Moritz Leppkes

  • August 30, 2024

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