Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial - Takeaways - MDSpire

Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial

  • By

  • Christian S. Hendershot

  • Michael P. Bremmer

  • Michael B. Paladino

  • Georgios Kostantinis

  • Thomas A. Gilmore

  • Neil R. Sullivan

  • Amanda C. Tow

  • Mark A. Prince

  • Sarah S. Dermody

  • Robyn Jordan

  • Sherry A. McKee

  • Paul J. Fletcher

  • Eric D. Claus

  • Klara R. Klein

  • May 26, 2026

  • 0 min

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  • 1

    Cigarette smoking causes over 8 million deaths annually and increases risks for cardiovascular diseases, type 2 diabetes, and cancer-related deaths.

  • 2

    GLP-1 receptor agonists, like semaglutide, show promise as a therapeutic option for smoking cessation and may mitigate weight gain post-cessation.

  • 3

    This phase 2a trial evaluated semaglutide monotherapy effects on smoking outcomes in non-treatment-seeking smokers over 9 weeks.

  • 4

    Participants received weekly semaglutide injections, with assessments of cigarette use, craving, withdrawal, and weight throughout the trial.

  • 5

    The study aims to explore the potential of semaglutide to reduce smoking behavior without concurrent smoking cessation interventions.

Original Source(s)

Once-Weekly Semaglutide in Adults With Daily Cigarette Use: A Randomized Clinical Trial

  • by Christian S. Hendershot, Michael P. Bremmer, Michael B. Paladino, Georgios Kostantinis, Thomas A. Gilmore, Neil R. Sullivan, Amanda C. Tow, Mark A. Prince, Sarah S. Dermody, Robyn Jordan, Sherry A. McKee, Paul J. Fletcher, Eric D. Claus, Klara R. Klein

  • May 26, 2026

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