Engagement of chymase-positive mast cells in myocardial damage associated with COVID-19 - Takeaways - MDSpire

Engagement of chymase-positive mast cells in myocardial damage associated with COVID-19

  • By

  • Andrey V. Budnevsky

  • Sergey N. Avdeev

  • Ekaterina D. Arkhipova

  • Djuro Kosanovic

  • Viktoria V. Shishkina

  • Tatiana A. Chernik

  • Evgeniy S. Ovsyannikov

  • Inna M. Perveeva

  • Andrey A. Filin

  • Roman E. Tokmachev

  • Alexander V. Pertsev

  • Elena E. Ivanova

  • Tatiana V. Samoylenko

  • Lyubov N. Antakova

  • May 7, 2026

  • 0 min

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  • 1

    Chymase-positive mast cells (MCs) are implicated in myocardial injury among patients who died from severe COVID-19.

  • 2

    A low density of cardiac MCs was observed, with a significant presence of degranulated chymase-positive cells.

  • 3

    Chymase-positive MCs correlated with severe COVID-19 indicators, including elevated troponin I levels and inflammatory markers.

  • 4

    Increased MC presence was associated with extensive interstitial and perivascular fibrosis, primarily type III collagen.

  • 5

    The study suggests targeting chymase-positive MCs may help mitigate cardiac complications in future coronavirus-related diseases.

Original Source(s)

Engagement of chymase-positive mast cells in myocardial damage associated with COVID-19

  • by Andrey V. Budnevsky, Sergey N. Avdeev, Ekaterina D. Arkhipova, Djuro Kosanovic, Viktoria V. Shishkina, Tatiana A. Chernik, Evgeniy S. Ovsyannikov, Inna M. Perveeva, Andrey A. Filin, Roman E. Tokmachev, Alexander V. Pertsev, Elena E. Ivanova, Tatiana V. Samoylenko, Lyubov N. Antakova

  • May 7, 2026

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