Mild metabolic profile may mask MASLD risk

Five reproducible MASLD subtypes showed distinct genetic profiles and patterns of metabolic comorbidity and disease progression.

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Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) can be classified into 5 distinct subgroups with unique genetic profiles.
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The study analyzed data from 2,042 patients in the Mayo Clinic cohort and 2,560 patients in the Tapestry cohort to derive these subgroups.
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C4, a polygenic subgroup, exhibited a mild metabolic profile but significant long-term liver risks, including fibrosis and cirrhosis.
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C5 demonstrated a liver-dominant disease trajectory with increased risks for MASH, fibrosis, and acute renal failure compared to C1.
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The classification of MASLD subgroups showed reproducibility across cohorts, indicating potential for individualized clinical management.

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