Unraveling the role of PPFIA1 in cancer: a comprehensive multi-omics analysis and functional validation from pan-cancer to pancreatic cancer - Takeaways - MDSpire

Unraveling the role of PPFIA1 in cancer: a comprehensive multi-omics analysis and functional validation from pan-cancer to pancreatic cancer

  • By

  • Shu Li

  • Hailin Jiang

  • Xiaojia Li

  • Tingting Jiang

  • Keping Xie

  • July 8, 2026

  • 0 min

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  • 1

    PPFIA1 is overexpressed in pancreatic adenocarcinoma compared to non-tumor tissue, indicating its potential role in cancer progression.

  • 2

    High levels of PPFIA1 correlate with poor prognosis in pancreatic cancer across multiple endpoints, suggesting its prognostic significance.

  • 3

    Genomic analyses revealed amplifications of PPFIA1 in head and neck cancers and mutations in endometrial carcinoma.

  • 4

    Knockdown of PPFIA1 in pancreatic cancer cells significantly reduced proliferation, migration, and invasion in vitro and in vivo.

  • 5

    Elevated PPFIA1 levels are associated with improved responses to immunotherapy in pan-cancer cohorts, highlighting its potential as a biomarker.

Original Source(s)

Unraveling the role of PPFIA1 in cancer: a comprehensive multi-omics analysis and functional validation from pan-cancer to pancreatic cancer

  • by Shu Li, Hailin Jiang, Xiaojia Li, Tingting Jiang, Keping Xie

  • July 8, 2026

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