OM-89 may curb postantibiotic E coli regrowth - Takeaways - MDSpire
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OM-89 may curb postantibiotic E coli regrowth

Lysosomal activation and increased intracellular antibiotic accumulation accompanied reduced bacterial regrowth across mouse and human bladder epithelial models.

  • By

  • Andrea Surnit

  • September 30, 2026

  • 5 min

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  • 1

    OM-89 enhances lysosomal function and intracellular antibiotic accumulation in bladder epithelial cells.

  • 2

    The study demonstrated that OM-89 reduced bacterial regrowth of uropathogenic E. coli following antibiotic treatment.

  • 3

    In mouse models, OM-89 showed the strongest effect on bacterial regrowth when administered during antibiotic treatment.

  • 4

    Transcriptomic profiling indicated that the lysosomal pathway was significantly induced during OM-89 treatment.

  • 5

    Pharmacologic inhibition of lysosomal acidification abolished the reduction in postantibiotic bacterial regrowth associated with OM-89.

Original Source(s)

OM-89 may curb postantibiotic E coli regrowth

  • by Andrea Surnit

  • September 30, 2026

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