Distinct roles of nutritional and inflammatory signatures in predicting pathological response versus long-term survival in locally advanced gastric cancer treated with neoadjuvant immunotherapy - Takeaways - MDSpire

Distinct roles of nutritional and inflammatory signatures in predicting pathological response versus long-term survival in locally advanced gastric cancer treated with neoadjuvant immunotherapy

  • By

  • Ying Dong

  • Lei Qian

  • YiChong Wang

  • Chunzhi Yuan

  • Wenjing Cui

  • Yue Shi

  • Jun Zhu

  • Xiaochen Ding

  • June 18, 2026

  • 0 min

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  • 1

    Neoadjuvant immunotherapy with chemotherapy improves outcomes in locally advanced gastric cancer (LAGC) but patient responses vary significantly.

  • 2

    The study evaluated the Prognostic Nutritional Index (PNI), Systemic Immune-inflammation Index (SII), and Creatinine to Cystatin C Ratio (CCR) as predictive biomarkers.

  • 3

    Patients achieving pathological complete response (pCR) had significantly better overall survival (OS) and disease-free survival (DFS) compared to non-pCR patients.

  • 4

    Low SII and high PNI and CCR levels were associated with improved OS and DFS, indicating their potential as prognostic indicators.

  • 5

    Integrating nutritional and inflammatory biomarkers into predictive models enhances risk stratification and personalized management for LAGC patients.

Original Source(s)

Distinct roles of nutritional and inflammatory signatures in predicting pathological response versus long-term survival in locally advanced gastric cancer treated with neoadjuvant immunotherapy

  • by Ying Dong, Lei Qian, YiChong Wang, Chunzhi Yuan, Wenjing Cui, Yue Shi, Jun Zhu, Xiaochen Ding

  • June 18, 2026

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