Spatial transcriptomics reveals an SPP1-centered immune–fibrotic axis associated with fibrosis-related tissue remodeling in IgG4-related disease - Takeaways - MDSpire

Spatial Transcriptomic Analysis Identifies an Immune-Fibrotic Pathway Centered on SPP1 in Tissue Remodeling Associated with IgG4-Related Disease

  • By

  • Motohisa Yamamoto

  • Ryuta Kamekura

  • Masaaki Uehara

  • Yuta Ichii

  • Kenichi Takano

  • July 17, 2026

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  • 1

    IgG4-related disease (IgG4-RD) is characterized by fibroinflammatory conditions leading to organ damage and fibrosis.

  • 2

    Spatial transcriptomic analysis revealed distinct fibrosis-associated tissue states in submandibular gland tissues from IgG4-RD patients.

  • 3

    SPP1-expressing macrophages were enriched in fibrosis-high regions, indicating a spatially defined fibrotic niche.

  • 4

    Immune network analysis showed remodeling of the immune microenvironment, particularly involving Tph-associated populations.

  • 5

    The study identifies an SPP1-associated immune-fibrotic niche, linking immune remodeling and fibrosis in IgG4-RD.

Original Source(s)

Spatial transcriptomics reveals an SPP1-centered immune–fibrotic axis associated with fibrosis-related tissue remodeling in IgG4-related disease

  • by Motohisa Yamamoto, Ryuta Kamekura, Masaaki Uehara, Yuta Ichii, Kenichi Takano

  • July 17, 2026

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