Efficacy and Safety of Tranexamic Acid in Sleeve Gastrectomy: A Double-Blind Randomized Controlled Trial - Takeaways - MDSpire

Efficacy and Safety of Tranexamic Acid in Sleeve Gastrectomy: A Double-Blind Randomized Controlled Trial

  • By

  • Mohammed Elshwadfy Nageeb

  • George Abdelfady Nashed

  • Mohamad Alaa Eldin Atef Elzayat

  • Mohamed Nasr Shazly

  • February 16, 2026

  • 0 min

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  • 1

    Tranexamic acid (TXA) significantly reduces intraoperative bleeding and complications in sleeve gastrectomy without increasing thromboembolic events.

  • 2

    A randomized controlled trial demonstrated that TXA administration leads to reduced hemoglobin decline and fewer staple-line interventions.

  • 3

    Meta-analyses indicate that TXA approximately halves the odds of postoperative bleeding and shortens hospitalization duration in bariatric surgery.

  • 4

    Despite its benefits, TXA remains under-utilized in metabolic and bariatric surgery due to concerns about venous thromboembolism risk.

  • 5

    Further multicenter studies are needed to optimize TXA dosing and confirm its safety across diverse metabolic and bariatric surgery populations.

Original Source(s)

Efficacy and Safety of Tranexamic Acid in Sleeve Gastrectomy: A Double-Blind Randomized Controlled Trial

  • by Mohammed Elshwadfy Nageeb, George Abdelfady Nashed, Mohamad Alaa Eldin Atef Elzayat, Mohamed Nasr Shazly

  • February 16, 2026

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