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Inflammatory signatures may distinguish dental caries
Combining IL-17 with TNF-alpha showed strong discrimination between carious lesions and healthy controls, but performance was more modest against gingival inflammation.
A salivary cytokine signature can distinguish carious lesions from healthy states, but has limited ability to differentiate from gingival inflammation.
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The study analyzed 65 patients aged 18 to 30 years with carious lesions, gingival inflammation, or healthy conditions using a multiplex assay.
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TNF-alpha was the strongest discriminator of carious lesions from healthy controls, while IL-6 was elevated in patients with carious lesions.
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The combination of IL-17 and TNF-alpha showed the highest discrimination for carious lesions, but modestly distinguished them from gingival inflammation.
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The study's findings are limited by a small sample size, narrow age range, and cross-sectional design, necessitating further validation.
