CD244 overexpression indicates NK cell dysfunction and tumor progression in diffuse large B-cell lymphoma - Takeaways - MDSpire

CD244 overexpression indicates NK cell dysfunction and tumor progression in diffuse large B-cell lymphoma

  • By

  • Yiming Yang

  • Biyang Zeng

  • Huimin Yang

  • Xin Liu

  • Peilin Li

  • Chao Mai

  • Shunhai Jian

  • Qiqi Zhu

  • July 7, 2026

  • 0 min

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  • 1

    CD244 is primarily expressed in NK cells within the tumor microenvironment of diffuse large B-cell lymphoma (DLBCL).

  • 2

    Elevated CD244 levels correlate with an immunosuppressive tumor microenvironment and worse clinicopathological features in DLBCL patients.

  • 3

    CD244 expression is associated with poorer clinical outcomes and increased responsiveness to immune checkpoint blockade therapy.

  • 4

    EAT2 is identified as the predominant intracellular adaptor for CD244, suggesting its role in NK cell metabolic dysregulation.

  • 5

    Regulatory mechanisms of CD244 expression in DLBCL may involve STAT3 activation in NK cells and ASXL3 mutations in tumor cells.

Original Source(s)

CD244 overexpression indicates NK cell dysfunction and tumor progression in diffuse large B-cell lymphoma

  • by Yiming Yang, Biyang Zeng, Huimin Yang, Xin Liu, Peilin Li, Chao Mai, Shunhai Jian, Qiqi Zhu

  • July 7, 2026

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