From inflammation to neurodegeneration: an exploratory pilot study of a diagnostic framework for progression in MS - Takeaways - MDSpire

From inflammation to neurodegeneration: an exploratory pilot study of a diagnostic framework for progression in MS

  • By

  • Tobias Hegelmaier

  • Khaldoon O. Al-Nosairy

  • Alexander Duscha

  • Antonia Lipp

  • Henrike Marie Nowitzki

  • Christiane Desel

  • Shahram Taherzadeh Amlashi

  • Léon Beyer

  • Klaus Gerwert

  • Hagen Thieme

  • Michael B. Hoffmann

  • Aiden Haghikia

  • May 20, 2026

  • 0 min

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  • 1

    The study investigates biomarkers to differentiate relapsing MS (RMS) from secondary progressive MS (SPMS) using a CART model.

  • 2

    Significant retinal nerve fiber layer thinning was observed in SPMS patients compared to RMS, indicating neurodegeneration.

  • 3

    Elevated serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (GFAP) levels were found in MS patients, particularly in SPMS.

  • 4

    The CART model achieved approximately 80% accuracy in classifying RMS and SPMS based on sNfL, GCIPL thickness, and monocyte subsets.

  • 5

    This research highlights the potential for a multimodal diagnostic approach to improve early identification of MS progression.

Original Source(s)

From inflammation to neurodegeneration: an exploratory pilot study of a diagnostic framework for progression in MS

  • by Tobias Hegelmaier, Khaldoon O. Al-Nosairy, Alexander Duscha, Antonia Lipp, Henrike Marie Nowitzki, Christiane Desel, Shahram Taherzadeh Amlashi, Léon Beyer, Klaus Gerwert, Hagen Thieme, Michael B. Hoffmann, Aiden Haghikia

  • May 20, 2026

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