Inborn errors of immunity in Low German Mennonite communities in Mexico: a case series and narrative literature review - Takeaways - MDSpire

Inborn errors of immunity in Low German Mennonite communities in Mexico: a case series and narrative literature review

  • By

  • Luisa Berenise Gámez-González

  • Saúl Oswaldo Lugo-Reyes

  • Rogelio Guzmán-Cotaya

  • Sara Elva Espinosa-Padilla

  • Luis Enrique Murguía-Favela

  • Marco Antonio Yamazaki-Nakashimada

  • June 24, 2026

  • 0 min

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  • 1

    Inborn errors of immunity (IEI) are more prevalent in consanguineous populations, such as Low German Mennonites in Mexico.

  • 2

    The study identified four patients with distinct IEI, including G6PC3 deficiency, XLA, and SCID, requiring specific therapies.

  • 3

    Genetic diagnoses were established using next-generation sequencing or whole-exome sequencing, following ACMG criteria.

  • 4

    A literature review revealed a broad spectrum of IEI in LGM populations, including various immunodeficiencies and disorders.

  • 5

    The study emphasizes the need for early diagnosis and genetic testing to improve outcomes in genetically isolated populations.

Original Source(s)

Inborn errors of immunity in Low German Mennonite communities in Mexico: a case series and narrative literature review

  • by Luisa Berenise Gámez-González, Saúl Oswaldo Lugo-Reyes, Rogelio Guzmán-Cotaya, Sara Elva Espinosa-Padilla, Luis Enrique Murguía-Favela, Marco Antonio Yamazaki-Nakashimada

  • June 24, 2026

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