Direct Amoxicillin Challenges for Penicillin Allergy Through Pediatric Primary Care Group Visits: A Pilot Study - Takeaways - MDSpire

Direct Amoxicillin Challenges for Penicillin Allergy Through Pediatric Primary Care Group Visits: A Pilot Study

  • By

  • Timothy G Chow

  • Candice Mercadel

  • Kristin S Alvarez

  • Madeline Kellam

  • David A Khan

  • Cesar Termulo

  • April 24, 2025

  • 0 min

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  • 1

    A pilot study evaluated direct amoxicillin challenges for assessing penicillin allergy in pediatric group visits.

  • 2

    Ninety-five percent of participants were delabeled from penicillin allergy with no severe reactions reported.

  • 3

    Direct oral challenge testing is a safe and effective strategy for most children with penicillin allergy labels.

  • 4

    Barriers to implementing penicillin allergy testing in pediatric settings include insufficient clinic time and staffing.

  • 5

    The study highlights the need for novel strategies to improve access to penicillin allergy testing in primary care.

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