Single-cell transcriptomic profiling of bronchial lymph nodes reveals mechanisms of PRRSV escape from host adaptive immunity - Takeaways - MDSpire

Single-cell transcriptomic profiling of bronchial lymph nodes reveals mechanisms of PRRSV escape from host adaptive immunity

  • By

  • Shu-yuan Guo

  • Xuan Wang

  • Jiaying Zhu

  • Chang Liu

  • Hao Zhou

  • Yaqi Chen

  • Yu Bai

  • Haoran Liu

  • Wen-hai Feng

  • July 15, 2026

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  • 1

    PRRSV infection leads to impaired adaptive immune responses, including delayed neutralizing antibody development and defective T-cell responses.

  • 2

    Single-cell RNA sequencing of bronchial lymph nodes revealed changes in immune cell composition following HP-PRRSV infection.

  • 3

    HP-PRRSV infection reduced multiple T-cell subsets while increasing B cell proportions, disrupting T-cell egress and intercellular communication.

  • 4

    The study identified a novel RAG1+ CD4+CD8+ double-positive T-cell subset associated with PRRSV, suggesting new avenues for research.

  • 5

    Findings provide insights into PRRSV immune evasion mechanisms, which may inform future vaccine design and antiviral strategies.

Original Source(s)

Single-cell transcriptomic profiling of bronchial lymph nodes reveals mechanisms of PRRSV escape from host adaptive immunity

  • by Shu-yuan Guo, Xuan Wang, Jiaying Zhu, Chang Liu, Hao Zhou, Yaqi Chen, Yu Bai, Haoran Liu, Wen-hai Feng

  • July 15, 2026

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