Cognitive impairment and prefrontal TGF-β1 elevation in a rat model of fatigue

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Chronic fatigue syndrome (CFS) is characterized by persistent fatigue and cognitive dysfunction, with an estimated global prevalence of 17 to 24 million individuals.
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The study utilized a rat model of fatigue induced by 10-day repetitive sleep deprivation to investigate TGF-β1 dysregulation and cognitive function.
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Rats in the fatigue group showed increased anxiety-like behavior and reduced spontaneous alternation rates in cognitive tests compared to controls.
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Prefrontal cortical TGF-β1 levels were significantly elevated in fatigued rats, while peripheral and striatal TGF-β1 levels did not differ between groups.
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The findings suggest a potential role for central TGF-β1 signaling in cognitive deficits associated with chronic fatigue, warranting further investigation.

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