Mechanisms of Epstein-Barr virus-associated autoimmunity: a comparative overview - Takeaways - MDSpire
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Comparative Analysis of Autoimmune Mechanisms Linked to Epstein-Barr Virus

  • By

  • Fathima Shabnam

  • Gulfaraz Khan

  • July 21, 2026

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  • 1

    Epstein-Barr virus (EBV) is linked to autoimmune diseases like multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis.

  • 2

    Shared mechanisms of EBV-related autoimmunity include immune dysfunction triggered by EBV latent proteins and molecular mimicry.

  • 3

    In multiple sclerosis, EBV is associated with CD8+ T-cell responses and molecular mimicry with neural antigens.

  • 4

    In systemic lupus erythematosus, EBV contributes to autoimmunity through mimicry with autoantigens and recurrent viral reactivation.

  • 5

    Host genetic variations, particularly in HLA alleles, influence susceptibility to EBV-associated autoimmune diseases.

Original Source(s)

Mechanisms of Epstein-Barr virus-associated autoimmunity: a comparative overview

  • by Fathima Shabnam, Gulfaraz Khan

  • July 21, 2026

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