Differential Effects of Aerobic, Resistance, and Combined Exercise on Skeletal Muscle Function in High-Fat Diet–Induced Obese Mice: Integration of Gut Microbiota and Metabolomics - Takeaways - MDSpire
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Comparative Impact of Aerobic, Resistance, and Combined Exercise on Skeletal Muscle Performance in Obese Mice Induced by High-Fat Diet: A Focus on Gut Microbiota and Metabolomic Changes

  • By

  • Wang, Yefan

  • Gao, Pengpeng

  • Hao, Zijun

  • Cui, Jinjing

  • Song, Faying

  • Wu, Lijun

  • May 28, 2026

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  • 1

    Aerobic, resistance, and combined exercise were tested for their effects on skeletal muscle performance in high-fat diet-induced obese mice.

  • 2

    All exercise groups showed improvements in endurance and grip strength compared to the high-fat diet group.

  • 3

    The combined exercise group exhibited the most significant enhancements in muscle fiber morphology and mitochondrial biogenesis.

  • 4

    Gut microbiota analysis revealed reduced α-diversity in the high-fat diet group, with the combined exercise group restoring diversity.

  • 5

    Metabolomic analysis identified 278 differential metabolites, with unique regulatory patterns linked to each exercise modality.

Original Source(s)

Differential Effects of Aerobic, Resistance, and Combined Exercise on Skeletal Muscle Function in High-Fat Diet–Induced Obese Mice: Integration of Gut Microbiota and Metabolomics

  • by Wang, Yefan , Gao, Pengpeng , Hao, Zijun , Cui, Jinjing , Song, Faying , Wu, Lijun

  • May 28, 2026

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