Berberine restrains the expansion of colorectal cancer organoids by blocking cell cycle progression and reducing lipid synthesis - Takeaways - MDSpire

Berberine restrains the expansion of colorectal cancer organoids by blocking cell cycle progression and reducing lipid synthesis

  • By

  • Hefei Tian

  • Tianshuo Zhao

  • Banghui Liu

  • Yujun Huang

  • Xi Wang

  • Zhenni Xu

  • Lingxiao Huang

  • Xudan Lei

  • Mingyue Qu

  • Qiongying Hu

  • Dengqun Liu

  • July 10, 2026

  • 0 min

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  • 1

    Berberine (BBR) is a natural compound from Coptis Chinensis with strong antitumor potential against colorectal cancer (CRC).

  • 2

    BBR significantly inhibits the growth of CRC organoids by inducing cell cycle arrest and increasing reactive oxygen species (ROS) levels.

  • 3

    RNA-Seq data indicates that BBR exerts direct cytotoxic effects on CRC organoids by disrupting gap junctions and epithelial barrier function.

  • 4

    BBR treatment leads to increased epithelial permeability and significantly blocks lipid synthesis in CRC organoids.

  • 5

    BBR shows no harmful impact on healthy colonic tissues while effectively suppressing the malignant phenotype of CRC organoids.

Original Source(s)

Berberine restrains the expansion of colorectal cancer organoids by blocking cell cycle progression and reducing lipid synthesis

  • by Hefei Tian, Tianshuo Zhao, Banghui Liu, Yujun Huang, Xi Wang, Zhenni Xu, Lingxiao Huang, Xudan Lei, Mingyue Qu, Qiongying Hu, Dengqun Liu

  • July 10, 2026

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