Impact of substructure radiation dose on health-related quality of life in children with brain tumors: a Pediatric Proton/Photon Consortium Registry (PPCR) study - Takeaways - MDSpire

Impact of substructure radiation dose on health-related quality of life in children with brain tumors: a Pediatric Proton/Photon Consortium Registry (PPCR) study

  • By

  • Mikaela Doig

  • Jae Lee

  • Young Kwok

  • Iain MacEwan

  • Suzanne Wolden

  • Keith Allison

  • Sara Dennehy

  • Benjamin Bajaj

  • Michala Short

  • Peter Gorayski

  • Eva Bezak

  • Torunn I. Yock

  • September 9, 2025

  • 0 min

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  • 1

    Survivors of childhood brain tumors face risks of impaired health-related quality of life (HRQoL) due to adverse effects from radiotherapy (RT).

  • 2

    Proton beam therapy (PBT) is preferred for pediatric brain tumors as it minimizes damage to normal tissues compared to traditional photon RT.

  • 3

    The study investigates the relationship between radiation dose to brain substructures and HRQoL in children treated with PBT for primary brain tumors.

  • 4

    Patient-reported outcome measures (PROMs) are essential for understanding the impact of cancer treatment on children's HRQoL.

  • 5

    Data were collected from the Pediatric Proton/Photon Consortium Registry, focusing on children under 22 years with available HRQoL data post-PBT.

Original Source(s)

Impact of substructure radiation dose on health-related quality of life in children with brain tumors: a Pediatric Proton/Photon Consortium Registry (PPCR) study

  • by Mikaela Doig, Jae Lee, Young Kwok, Iain MacEwan, Suzanne Wolden, Keith Allison, Sara Dennehy, Benjamin Bajaj, Michala Short, Peter Gorayski, Eva Bezak, Torunn I. Yock

  • September 9, 2025

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