Evaluation of the Safety and Effectiveness of Calcitonin Gene-Related Peptide Antagonists in Treating Cluster Headaches: A Systematic Review and Meta-Analysis

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Cluster headaches (CH) cause severe unilateral pain and significant socioeconomic burden, reducing productivity by 65% during active attack periods.
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Current CH treatments include acute therapies like high-flow oxygen and preventive options, but many have limitations such as delayed onset and monitoring requirements.
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Calcitonin Gene-Related Peptide (CGRP) antagonists are emerging as targeted therapies for CH, with monoclonal antibodies and small-molecule receptor antagonists available.
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This systematic review and meta-analysis aims to evaluate the safety and efficacy of CGRP antagonists for CH by synthesizing data from randomized controlled trials.
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The study includes trials meeting specific criteria and assesses safety outcomes like treatment-emergent adverse events and efficacy in reducing weekly attack frequency.

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