Postoperative pain evaluation in laparoscopic radical prostatectomy surgery using tranexamic acid: analgesia?, hyperalgesia??

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Tranexamic acid (TXA) is used in laparoscopic surgeries to minimize intraoperative blood loss but its role in postoperative pain management is unclear.
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The study aimed to evaluate whether intravenous TXA enhances analgesia or contributes to hyperalgesia in patients undergoing laparoscopic radical prostatectomy.
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VAS scores indicated that pain levels at 0 and 6 hours were significantly lower in the control group compared to the TXA group.
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The TXA group required more rescue analgesia within the first 24 hours postoperatively, with a shorter time to first rescue analgesia.
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No significant differences were found between groups in demographic, hemodynamic data, or side effects, indicating comparable baseline characteristics.

World Journal Of Urology

by Gülten Arslan, Nihan Yaman Mammadov, Ceren Önal, Fırat Mavi, Fatih Doğu Geyik, Banu Eler Çevik
May 13, 2025

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