Efficacy and Safety of Neoadjuvant Therapies for High-Risk and Locally Advanced Prostate Cancer in Older Adults: A Systematic Review and Network Meta-Analysis - Takeaways - MDSpire

Efficacy and Safety of Neoadjuvant Therapies for High-Risk and Locally Advanced Prostate Cancer in Older Adults: A Systematic Review and Network Meta-Analysis

  • By

  • Yuan, Wenling

  • Wang, Yu

  • Liu, Qi

  • Tian, Fangyuan

  • Guo, Mengran

  • May 8, 2026

  • 0 min

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  • 1

    The study evaluates neoadjuvant treatments for high-risk prostate cancer in elderly patients, focusing on their efficacy and safety.

  • 2

    Novel neoadjuvant hormonal therapy (NNHT) ranked highest for improving pathological outcomes, including surgical margin status.

  • 3

    NNHT demonstrated the best rates for positive surgical margins and prostate-specific antigen reduction among the treatments analyzed.

  • 4

    Despite its effectiveness, NNHT was linked to the highest frequency and severity of adverse events, indicating a trade-off.

  • 5

    The findings support prioritizing NNHT in future trials aimed at assessing long-term survival and safety in older adults.

Original Source(s)

Efficacy and Safety of Neoadjuvant Therapies for High-Risk and Locally Advanced Prostate Cancer in Older Adults: A Systematic Review and Network Meta-Analysis

  • by Yuan, Wenling , Wang, Yu , Liu, Qi , Tian, Fangyuan , Guo, Mengran

  • May 8, 2026

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