Exploring the human brain: spatial transcriptomics challenges and approaches in post-mortem analysis - Takeaways - MDSpire

Exploring the human brain: spatial transcriptomics challenges and approaches in post-mortem analysis

  • By

  • Sean Chang

  • Christelle El Haj

  • Jan Mulder

  • Lipin Loo

  • Asheeta A Prasad

  • December 5, 2025

  • 0 min

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  • 1

    Studying the human brain presents complex challenges due to its intricate structure and diverse cell types.

  • 2

    Spatial transcriptomics (ST) provides high-resolution insights into mRNA expression at single-cell resolution.

  • 3

    Sequencing-based ST captures mRNA transcripts while preserving spatial information, enabling whole-transcriptome analysis.

  • 4

    Challenges in human brain analysis include tissue size limitations and potential biases in transcript detection.

  • 5

    The review discusses various ST platforms and offers guidelines for researchers to navigate these challenges.

Original Source(s)

Exploring the human brain: spatial transcriptomics challenges and approaches in post-mortem analysis

  • by Sean Chang, Christelle El Haj, Jan Mulder, Lipin Loo, Asheeta A Prasad

  • December 5, 2025

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