New Medications for Dry Eye and Presbyopia - Takeaways - MDSpire

New Medications for Dry Eye and Presbyopia

Topical miotics are approved for use in all adults with presbyopia, including post-LASIK patients and pseudophakes, and acoltremon is a treatment option for multiple dry eye subtypes, either as primary therapy or adjunctive treatment.

  • By

  • Sarah Fackler, managing editor, Optometric Management

  • January 1, 2026

  • 4 min

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  • 1

    New topical prescription therapies for presbyopia and dry eye disease include pilocarpine, aceclidine, and acoltremon.

  • 2

    Pilocarpine 0.4% shows significant improvement in near visual acuity, with 52.9% of patients achieving 20/40 DCNVA or better by day 15.

  • 3

    Aceclidine 1.44% has a dosing regimen of 2 drops once daily and demonstrates a rapid onset of effect, with 71% of participants improving within 0.5 hours.

  • 4

    Acoltremon 0.003% stimulates tear production and met primary endpoints in phase 3 trials, showing significant improvements in dry eye symptoms.

  • 5

    Topical miotics are approved for all adults with presbyopia, including post-LASIK patients, while acoltremon is suitable for various dry eye subtypes.

Original Source(s)

New Medications for Dry Eye and Presbyopia

  • by Sarah Fackler, managing editor, Optometric Management

  • January 1, 2026

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