The modifying effect of diabetes on the association between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular risk: a systematic review and meta-analysis

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This meta-analysis included 27 cohort studies with 949,043 participants to evaluate the TG/HDL-C ratio and cardiovascular risk.
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The TG/HDL-C ratio was associated with cardiovascular events and all-cause mortality in both diabetic and non-diabetic populations.
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Stronger associations with stroke and coronary heart disease were observed in individuals with diabetes compared to those without.
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The certainty of evidence regarding the TG/HDL-C ratio's associations ranged from very low to moderate.
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Future large-scale studies are needed to validate findings and explore the mechanisms of diabetes's modifying effect.

Frontiers In Cardiovascular Medicine

by Hao Bai, Lihua Xia, Lingqiao Song, Zeyuan Long, Youxing Wu, Jiangyun Ru, Yuanzhi Li, Xing Ni, Zhangyi Wang, Li Liao
June 24, 2026

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