Commentary: Pemphigoid associated with quinolone antibiotics: a real-world pharmacovigilance study of the FDA adverse event reporting system and literature-based evidence - Takeaways - MDSpire

Analysis of Pemphigoid Linked to Quinolone Antibiotics: Insights from FDA Adverse Event Reports and Literature Review

  • By

  • Hai-Hong Lin

  • Kai-Li Mao

  • Liu-Cheng Li

  • Huan-Hao Zhou

  • July 17, 2026

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  • 1

    Li et al. conducted a pharmacovigilance analysis linking quinolone antibiotics to pemphigoid using the FDA Adverse Event Reporting System.

  • 2

    The study identified significant disproportionality signals for ofloxacin, levofloxacin, and ciprofloxacin, primarily in elderly females.

  • 3

    The commentary highlights methodological confounders and the need for sensitivity analyses to validate the quinolone signal.

  • 4

    Nine case reports included in the study serve as supportive qualitative evidence but do not provide independent statistical validation.

  • 5

    The original study lacks adherence to established pharmacovigilance guidelines, limiting transparency and generalizability of findings.

Original Source(s)

Commentary: Pemphigoid associated with quinolone antibiotics: a real-world pharmacovigilance study of the FDA adverse event reporting system and literature-based evidence

  • by Hai-Hong Lin, Kai-Li Mao, Liu-Cheng Li, Huan-Hao Zhou

  • July 17, 2026

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