Clinical value of IL-17-targeted intervention in tissue injury repair: from bidirectional mechanisms to therapeutic strategies - Takeaways - MDSpire
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The Therapeutic Potential of Targeting IL-17 in Tissue Repair: Exploring Dual Mechanisms and Treatment Approaches

  • By

  • Wenyu An

  • Xinyi Ma

  • Runxue Guan

  • Yufen Zhao

  • Nina Yang

  • Liang Jin

  • Yang Jian

  • Shaoying Gao

  • Zairong Wei

  • June 2, 2026

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  • 1

    IL-17 is a pleiotropic cytokine that influences tissue repair by regulating inflammatory mediators, growth factors, and matrix metalloproteinases.

  • 2

    IL-17 has biphasic effects during tissue repair, promoting healing in the acute phase while potentially causing fibrosis in the chronic phase.

  • 3

    The dual roles of IL-17 are influenced by factors such as cellular origin, injury phase, and the local microenvironment.

  • 4

    Current research on IL-17's effects is largely organ-specific and lacks a comprehensive understanding of its regulatory mechanisms.

  • 5

    Insights into IL-17's duality can inform the development of tailored therapeutic strategies for various clinical scenarios.

Original Source(s)

Clinical value of IL-17-targeted intervention in tissue injury repair: from bidirectional mechanisms to therapeutic strategies

  • by Wenyu An, Xinyi Ma, Runxue Guan, Yufen Zhao, Nina Yang, Liang Jin, Yang Jian, Shaoying Gao, Zairong Wei

  • June 2, 2026

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