Predictive value of antioxidant and thyroid function indicators for non-suicidal self-injury in adolescents with major depressive disorder - Takeaways - MDSpire

Predictive value of antioxidant and thyroid function indicators for non-suicidal self-injury in adolescents with major depressive disorder

  • By

  • Kefei Yang

  • Lewei Liu

  • Xianlong Zhang

  • Xianlin Sun

  • Pei Tang

  • Kai Zhang

  • Huanzhong Liu

  • June 1, 2026

  • 0 min

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  • 1

    The study found a 57.4% prevalence of non-suicidal self-injury (NSSI) among adolescents with major depressive disorder (MDD).

  • 2

    Independent predictors of NSSI included female sex, HAMD-17 score, indirect bilirubin, and TSH levels, as identified by multivariate logistic regression.

  • 3

    The combination of sex, HAMD-17 score, indirect bilirubin, and TSH demonstrated significant predictive ability for NSSI with an AUC of 0.776.

  • 4

    Reduced levels of indirect bilirubin and elevated TSH levels may underlie the pathophysiology of NSSI in adolescents with MDD.

  • 5

    Targeted interventions focusing on antioxidant defense and thyroid function may provide new therapeutic strategies for managing NSSI.

Original Source(s)

Predictive value of antioxidant and thyroid function indicators for non-suicidal self-injury in adolescents with major depressive disorder

  • by Kefei Yang, Lewei Liu, Xianlong Zhang, Xianlin Sun, Pei Tang, Kai Zhang, Huanzhong Liu

  • June 1, 2026

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