Prognostic significance and model evaluation of the modified advanced lung cancer inflammation index in locally advanced resectable gastric cancer patients with neoadjuvant chemotherapy - Takeaways - MDSpire

Prognostic significance and model evaluation of the modified advanced lung cancer inflammation index in locally advanced resectable gastric cancer patients with neoadjuvant chemotherapy

  • By

  • Weidong Xie

  • Yaoyu Song

  • Zhaojie Yu

  • Huanhao Zhang

  • Shaoliang Han

  • June 4, 2026

  • 0 min

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  • 1

    This study evaluated the prognostic value of the modified Advanced Lung Cancer Inflammation Index (mALI) in gastric cancer patients undergoing neoadjuvant chemotherapy.

  • 2

    A total of 209 patients with locally advanced resectable gastric cancer were included, with mALI assessed using sex-specific quartiles.

  • 3

    High mALI was independently associated with improved overall survival (OS), with a hazard ratio of 0.52 (95% CI: 0.30-0.89, P=0.017).

  • 4

    The mALI-based nomogram demonstrated acceptable internal performance, with an apparent C-index of 0.765 and an optimism-corrected C-index of 0.750.

  • 5

    The study concluded that preoperative mALI after NAC is associated with OS, but external validation is needed before clinical implementation.

Original Source(s)

Prognostic significance and model evaluation of the modified advanced lung cancer inflammation index in locally advanced resectable gastric cancer patients with neoadjuvant chemotherapy

  • by Weidong Xie, Yaoyu Song, Zhaojie Yu, Huanhao Zhang, Shaoliang Han

  • June 4, 2026

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