Comparative efficacy of continuous versus intermittent administration of furosemide in acute heart failure: an updated systematic review and meta-analysis of 22 RCTs - Takeaways - MDSpire

Comparative efficacy of continuous versus intermittent administration of furosemide in acute heart failure: an updated systematic review and meta-analysis of 22 RCTs

  • By

  • Juan Cai

  • Danpeng Wang

  • Ling Yang

  • Ye Yuan

  • June 22, 2026

  • 0 min

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  • 1

    Acute heart failure affects an estimated 56.2 million individuals globally, with significant increases observed since 1990.

  • 2

    Intravenous loop diuretics, primarily furosemide, are essential for decongestive therapy in acute heart failure.

  • 3

    The systematic review included 22 randomized controlled trials with 2,633 participants comparing continuous and intermittent furosemide administration.

  • 4

    Continuous intravenous furosemide significantly improved freedom from congestion and weight loss compared to intermittent administration.

  • 5

    No significant advantage was found for long-term survival or other outcomes between continuous and intermittent furosemide administration.

Original Source(s)

Comparative efficacy of continuous versus intermittent administration of furosemide in acute heart failure: an updated systematic review and meta-analysis of 22 RCTs

  • by Juan Cai, Danpeng Wang, Ling Yang, Ye Yuan

  • June 22, 2026

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