Survival after curative hepatectomy for hepatocellular carcinoma in patients with and without MAFLD: a western cohort study - Takeaways - MDSpire
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Outcomes Following Curative Hepatectomy for Hepatocellular Carcinoma in Patients With and Without Metabolic-Associated Fatty Liver Disease: Insights from a Western Cohort Study

  • By

  • Michele Molinari

  • Vrishketan Sethi

  • Christof Kaltenmeier

  • Abiha Abdullah

  • Berkay Demirors

  • Matthew Yu-Sheng Lin

  • Jason Mial-Anthony

  • Dooman Arefan

  • Shandong Wu

  • Christopher Buros

  • Hao Liu

  • Charbel Elias

  • Marta Minervini

  • Samer Tohme

  • Xingyu Zhang

  • David Geller

  • Alessandro Furlan

  • July 16, 2026

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  • 1

    The study evaluated outcomes of curative hepatic resection for hepatocellular carcinoma (HCC) in patients with and without metabolic-associated fatty liver disease (MAFLD).

  • 2

    Among 156 patients, 57.1% were classified as MAFLD-positive, who were older, more frequently obese and diabetic, and less likely to have cirrhosis.

  • 3

    MAFLD-positive patients had different surgical approaches, with more open or hybrid resections compared to minimally invasive techniques in MAFLD-negative patients.

  • 4

    After multivariable adjustment, MAFLD was not independently associated with overall survival or disease-free survival following hepatic resection.

  • 5

    Cirrhosis, impaired performance status, elevated alpha-fetoprotein, and greater tumor burden were identified as principal predictors of postoperative outcomes.

Original Source(s)

Survival after curative hepatectomy for hepatocellular carcinoma in patients with and without MAFLD: a western cohort study

  • by Michele Molinari, Vrishketan Sethi, Christof Kaltenmeier, Abiha Abdullah, Berkay Demirors, Matthew Yu-Sheng Lin, Jason Mial-Anthony, Dooman Arefan, Shandong Wu, Christopher Buros, Hao Liu, Charbel Elias, Marta Minervini, Samer Tohme, Xingyu Zhang, David Geller, Alessandro Furlan

  • July 16, 2026

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