Factors associated with death in severe dengue: a retrospective cohort study in Espírito Santo, Brazil, 2020-2024 - Takeaways - MDSpire
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Determinants of Mortality in Severe Dengue: A Retrospective Cohort Analysis from Espírito Santo, Brazil, 2020-2024

  • By

  • Creuza Rachel Vicente

  • João Paulo Cola

  • Ana Paula Brioschi dos Santos

  • Theresa Cristina Cardoso

  • Crispim Cerutti Junior

  • Eng Eong Ooi

  • Stefano Gobbi

  • Julia Luch dos Santos

  • Angelica Espinosa Miranda

  • Kuan Rong Chan

  • September 18, 2026

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  • 1

    The paper cites an estimated 390 million dengue infections annually worldwide, approximately 96 million of which are symptomatic. Severe dengue can involve shock, severe bleeding, or organ dysfunction.

  • 2

    Brazil reported more than 6000 dengue-related deaths and more than 6.5 million cases in 2024, according to surveillance data cited in the paper.

  • 3

    This retrospective cohort study examined mortality-associated factors among 251 patients with laboratory-confirmed severe dengue in Espírito Santo, Brazil, from 2020 through 2024. Of these, 117 (46.6%) died.

  • 4

    Researchers used the state’s eSUS-VS disease notification system to analyze demographic and clinical factors. Exploratory analyses compared patients aged <60 years and ≥60 years.

  • 5

    Eligibility required laboratory-confirmed dengue with severe plasma leakage causing shock or respiratory distress, severe bleeding, or severe organ involvement. Mortality was predominantly associated with advanced hemodynamic instability.

Original Source(s)

Factors associated with death in severe dengue: a retrospective cohort study in Espírito Santo, Brazil, 2020-2024

  • by Creuza Rachel Vicente, João Paulo Cola, Ana Paula Brioschi dos Santos, Theresa Cristina Cardoso, Crispim Cerutti Junior, Eng Eong Ooi, Stefano Gobbi, Julia Luch dos Santos, Angelica Espinosa Miranda, Kuan Rong Chan

  • September 18, 2026

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