Herbal targeting of mitochondrial dynamic proteins in low-density lipoprotein driven atherosclerosis in vitro - Takeaways - MDSpire

Targeting Mitochondrial Dynamics with Herbal Extracts in Atherosclerosis Induced by Low-Density Lipoprotein: An In Vitro Study

  • By

  • Zhanna Dzampaeva

  • Rodion Saveljev

  • July 21, 2026

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  • 1

    Mitochondrial dysfunction is a key factor in endothelial injury during atherogenesis, particularly influenced by oxidized LDL.

  • 2

    Ethanolic extracts from Rosmarinus officinalis, Cynara cardunculus, and Myrtus communis were evaluated for their protective effects on endothelial cells.

  • 3

    The extracts preserved mitochondrial membrane potential and reversed pro-fission gene expression in a model of ox-LDL-induced damage.

  • 4

    Cynara cardunculus significantly upregulated PINK1 and PARKIN, enhancing mitophagy, while the other extracts favored receptor-mediated clearance.

  • 5

    Herbal extracts improved antioxidant defenses and reduced inflammation, suggesting potential for early atherosclerosis prevention through mitochondrial quality control.

Original Source(s)

Herbal targeting of mitochondrial dynamic proteins in low-density lipoprotein driven atherosclerosis in vitro

  • by Zhanna Dzampaeva, Rodion Saveljev

  • July 21, 2026

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