From mechanical triggering to metabolic-inflammatory driving: a new paradigm of knee osteoarthritis pathogenesis - Takeaways - MDSpire

From mechanical triggering to metabolic-inflammatory driving: a new paradigm of knee osteoarthritis pathogenesis

  • By

  • Manli Yan

  • Xin Zhang

  • Hao Liu

  • Qingyang Kang

  • Jianjiang Li

  • Baoqing Zhang

  • Dingkun Lin

  • Xiang Li

  • May 18, 2026

  • 0 min

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  • 1

    Knee osteoarthritis (KOA) is a major global health issue and a leading cause of disability among middle-aged and elderly individuals.

  • 2

    The understanding of KOA has shifted from a mechanical wear-and-tear model to recognizing metabolic dysfunction and inflammation as key drivers.

  • 3

    Obesity may exacerbate KOA by acting as a metabolic hub, linking systemic factors to local joint inflammation through adipokine signaling.

  • 4

    The new paradigm of KOA emphasizes mechanical initiation, metabolic-inflammatory driving, and heightened mechanical sensitivity in its pathogenesis.

  • 5

    Clinical management of KOA should transition towards integrated metabolic strategies, including targeted nutritional interventions and metabolic-modulating therapies.

Original Source(s)

From mechanical triggering to metabolic-inflammatory driving: a new paradigm of knee osteoarthritis pathogenesis

  • by Manli Yan, Xin Zhang, Hao Liu, Qingyang Kang, Jianjiang Li, Baoqing Zhang, Dingkun Lin, Xiang Li

  • May 18, 2026

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