Response to Matters Arising about the etiology of ventilator-associated pneumonia in the European POS-VAP cohort - Takeaways - MDSpire

Response to Matters Arising about the etiology of ventilator-associated pneumonia in the European POS-VAP cohort

  • By

  • Marlieke E. A. de Kraker

  • Holly Jackson

  • Ana Catalina Hernandez Padilla

  • C. Henri van Werkhoven

  • Bruno Francois

  • June 18, 2026

  • 0 min

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  • 1

    Ventilator-associated pneumonia (VAP) pathogens vary by region, patient demographics, and risk factors for multi-drug resistant infections.

  • 2

    In the POS-VAP cohort, Gram-negative pathogens accounted for 66% of microbiologically evaluable VAP cases, with Staphylococcus aureus being the most common.

  • 3

    Differences in VAP pathogen distribution may be influenced by patient case mix, with S. aureus prevalent in trauma and stroke patients.

  • 4

    The proportion of P. aeruginosa VAP increased from early to late VAP, highlighting the importance of timing in pathogen identification.

  • 5

    Microbiological confirmation methods varied across studies, with POS-VAP relying more on respiratory samples compared to blood cultures in other cohorts.

Original Source(s)

Response to Matters Arising about the etiology of ventilator-associated pneumonia in the European POS-VAP cohort

  • by Marlieke E. A. de Kraker, Holly Jackson, Ana Catalina Hernandez Padilla, C. Henri van Werkhoven, Bruno Francois

  • June 18, 2026

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