Implementation of an Online Drug–Drug Interaction Screener for the STRIVE Ensitrelvir Trial for COVID-19 - Takeaways - MDSpire

Implementation of an Online Drug–Drug Interaction Screener for the STRIVE Ensitrelvir Trial for COVID-19

  • By

  • Joshua P Havens

  • Nayon Kang

  • Lucy Chung

  • Courtney V Fletcher

  • Page Crew

  • Jacqueline Nordwall

  • Lianne Siegel

  • Katrina Harper

  • Birgit Grund

  • Marcelo Losso

  • Shikha Vasudeva

  • Kyle C Molina

  • Adit A Ginde

  • Ryosuke Shimizu

  • Ahmad Mourad

  • Alpha Diallo

  • Mina Pak

  • Anne Davis-Karim

  • Phiona Nabaggala

  • Alfredo J Mena Lora

  • Derek W Russell

  • Sho Saito

  • Jason V Baker

  • for the STRIVE Ensitrelvir Trial Study Group and the STRIVE Network

  • June 11, 2025

  • 0 min

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  • 1

    Ensitrelvir is an antiviral for COVID-19 with significant drug-drug interactions involving CYP3A and P-glycoprotein.

  • 2

    The STRIVE trial evaluates ensitrelvir's efficacy and safety in hospitalized adults with COVID-19 and lower respiratory tract involvement.

  • 3

    An online DDI screener was developed to manage drug interactions, categorizing medications as permitted, prohibited, or conditionally permitted.

  • 4

    The DDI screener expanded from 615 to 1182 medications over 18 months, with significant user engagement and feedback from trial sites.

  • 5

    Effective DDI management in clinical trials requires a multidisciplinary approach and real-time feedback to ensure patient safety.

Original Source(s)

Implementation of an Online Drug–Drug Interaction Screener for the STRIVE Ensitrelvir Trial for COVID-19

  • by Joshua P Havens, Nayon Kang, Lucy Chung, Courtney V Fletcher, Page Crew, Jacqueline Nordwall, Lianne Siegel, Katrina Harper, Birgit Grund, Marcelo Losso, Shikha Vasudeva, Kyle C Molina, Adit A Ginde, Ryosuke Shimizu, Ahmad Mourad, Alpha Diallo, Mina Pak, Anne Davis-Karim, Phiona Nabaggala, Alfredo J Mena Lora, Derek W Russell, Sho Saito, Jason V Baker, for the STRIVE Ensitrelvir Trial Study Group and the STRIVE Network

  • June 11, 2025

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