Editorial: Discovery of small molecule lead compounds: a driving force to unravel new anti-cancer targets and mechanisms, volume III

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Natural products are crucial for developing novel anticancer agents, particularly in overcoming multi-drug resistance.
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Parthenolide significantly modulates amino acid metabolism and oxidative stress in lung adenocarcinoma, targeting GCTG.
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Wogonin shows therapeutic potential against prolactinoma by inhibiting the PI3K/AKT pathway and enhancing sensitivity to bromocriptine.
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Novel VEGFR-2 inhibitors identified from natural products demonstrate strong binding and favorable properties for treating papillary thyroid carcinoma.
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Steroidal saponins are promising for cancer therapy but face challenges like low bioavailability and toxicity, necessitating further research.

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