Cerebral perfusion pressure trajectories and cumulative exposure metrics predict in-hospital mortality in acute brain injury

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This study identified four cerebral perfusion pressure (CPP) trajectory phenotypes in acute brain injury patients: Stable Normal, Gradual Recovery, Labile Improvement, and Rapid Decline.
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Mortality risk increased progressively from Stable Normal to Rapid Decline, with hazard ratios ranging from 1.720 to 5.313, indicating significant associations with in-hospital mortality.
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Higher cumulative CPP metrics were consistently linked to lower in-hospital mortality, emphasizing the importance of dynamic CPP management in acute brain injury.
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Survival analyses demonstrated clear separation in survival probabilities across CPP phenotypes, with Stable Normal showing the highest and Rapid Decline the lowest.
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The study concluded that CPP trajectory provides modest incremental prognostic information and warrants further prospective validation in clinical settings.

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